The Definitive List of Major Pharmaceutical Companies

In 2017, it was estimated that the pharmaceutical market was at around USD 1.11 trillion, and it was estimated to hit over USD 1.43 trillion by 2020.

The global pharmaceutical market is shared mainly between North America, Western Europe, and the Asian Pacific.

Research efforts and developments have assisted major companies to take a lead despite lots of competitions from the patent expiry and generics.

Below are classifications and definitive lists of major pharmaceutical companies based on their revenues, annual revenue growth, and other performance criteria.

So the statistic below highlights pharmaceutical financial worthy and each company’s product diversity portfolio.

Johnson & Johnson

This is a US-based pharmaceutical company that is also a consumer good manufacturers. Its subsidiaries deal with manufacturing, research development, and selling of pharm meds. This firm offers medicine majorly in HIV/AIDS, arthritis, hepatitis c and also digestive conditions. In 2017 J&J was the top seller of drugs comprising Remicade, Stelara, and the Invega Sustena. J&J is not a new company, but it has consumers and appreciated for its quality in drugs and medicines. It is not just known in the US but it delivers drugs in so many nations across the globe. It works to serve both consumer and retailers.


This is a special pharmaceutical firm that is from the USA, their drugs are research-based. It deals with wellness, preventive and treatment for various diseases all around therapeutic areas. This company works through research discoveries, innovating in medicals. They have establishment in health business regions. This organization offers medicine in immunology ecology and cardiology as their main area of expertise and specialization.

F. Hoffmann-La Roche Ltd

Commonly known as Roche is research centered healthcare from Switzerland that develops, produces and delivers innovative therapeutics, diagnostic instruments and investigations. It provides immunology, diabetes, ophthalmology, neuroscience, and infectious disease. This company signed a mergers agreement to possess oncology based Biopharmaceutical firm. This acquisition was achieved in the first quarter of 2018. This firm is among the top five having followers and trustee all over the world and their production serves a great number of people.


This company comes from the USA, it is a biopharmaceutical firm that develops and sells advanced medicines for curing gastroenterology, oncology, neurology, rheumatology and virology disorders and other extreme conditions that are metabolic-related. This company was the top seller of Imbruvica, Humira, and HCV. This company is also among the top ten best sellers and the largest in the whole world, its product quality is undeniable. Their online service is very efficient and easy to purchase directly from their website.


This company is founded and is from France it’s associated with research, developing, producing and marketing pharmaceutical solutions. This company is famous for producing non-prescribed medicines and drugs commonly referred to as over the counter (OTC), the classification having drugs majorly for the nervous system, oncology, diabetes, cardiovascular, vaccines and other internal medicines. It was able to acquire biopharmaceutical firms Ablynx and Bioverative. This very famous company that has been working for quite some time, it has been trusted by many individuals across the globe. It has both physical and online location which gives it the power to survive the competition.


This company is a super huge farm that is recognized globally and is founded in Basel, Switzerland. The company’s portfolio shows that is also a research-based that deals with innovative medicine, manufacturing and selling drugs especially in biological therapies and pharmaceutical in various diseases areas comprising oncology, eye care, genetics, immunology, neurology, and cardiology. The value of this firm is undeniable and is not limited to any specific solutions but deals with a broad solution and aims at achieving perfect human care. With their everyday research, they bring the hope of unlocking common challenges in the medical industry.


This is among the top pharmaceuticals that is founded in the UK, many consumers, especially in the UK, has unwavering trust in it. It sells medicine based on research development, manufacturing and also distributing prescribed medicine, vaccines and also has a big consumer care ability. GlaxoSmithKline is known to offer a solution in disease areas like dermatology, respiratory diseases, diabetes, cardiovascular, and gynecology. It has various top-selling drugs since is also not a newbie in the pharmaceutical drug market. It has consumer base mainly in the UK and other parts of the world.

Sinopharm Group

This company is from China, it has been playing a big role in the medical industry and hence listed one of the best at position 22 in fact according to Chinese value ranking and was able to acquire the pharmaceutical and health products seller and distributor Shanghai Pudong New Area Medicine and Herbs. It is known to operate and deal in wholesaling and retailing of pharmaceutical products. It is a known to be quality with their main specialization area as pharmaceutical distribution and also a retail pharmacy.

Merck & Co.

Merck is a well-known company that is founded in the USA and is commonly known as MSD in Canada and even outside the United States. This company has a big role in the medical industry as it deals majorly in animal health products and also human health .has more solutions in vaccines, prescribed medicines and biological therapies. Moreover, Merck offers solutions for fertility, oncology, neurodegenerative disorders, and endocrinology. The company is well known across the united states and appreciated by the animal keepers and farms for they have gone a mile in finding solution affecting animals, giving more research on animal disease and developing a solution for them. Their drugs are well accepted even from abroad, and their services are awesome.


Our definitive of top pharmaceutical companies that are major distributors in the world of medicine does not end there are many of them but described above are major ones. The fact that these companies are largest in terms of financial and market doesn’t mean the others that are not mentioned are of low-class manufacturing, no they still have a share in the pharmaceutical industry. The description of the above companies shoes that they are real-world breadwinners as most of them deal in drugs and medicines that are research-based, from vaccination that is preventive, curative medicines and carry out experiments to develop the new solution to disorder problems that distract smooth running of human and animal life.

How to Overcome Opioid Addiction

The use of opioids is widely spread.

In the US over 20% of the population is using it for non-medical reasons.

Even NPR thinks it’s a national issue.

And this figure is only for the documented cases.

In reality, it could be worse than it seems on the face of it.

The True Story of Addiction

Well, the story of addiction does not end well.

It does not matter the kind of substance you are hooked up to; you are in for a rough ride.

If you are wondering on how to overcome opioid addiction, then you came to the right place.

This article covers some of the best ways you can shake off your opioid dependence.

Accept you need help.

Addiction is never easy on anyone.

No matter how strong you think you are; it will get to a point where you cannot help yourself.

It is time you accept that things have spun out of control and you could use some help.

You do not have to make it public; your couple or a dear friend should be able to understand you.

Physical Activities can be used to treat addiction.

Get into exercise For anyone trying to get out of an addiction, exercising is one thing you need in your menu of daily activities.

From studies, physical exercise accelerates the pace at which harmful substances are flushed out of your body.

It does not have to be grinding all the day at the gym.

You can run, take a leisure walk or do whatever fits into your physical activity.

Exercising will also keep your mind occupied and free from the thoughts of getting high.

Find a hobby Sometimes being idle lets your mind wander and the only thing you would want is getting high.

Keeping your mind busy somehow has the potential to help with addiction.

What other things can you do to pass time? Is it playing the guitar, drawing or dancing? Whatever it is, find time to do it.

Keep yourself busy, and you will be surprised how effective this can be in overcoming addictions.

Cut loose bad company For those who got into the addiction out of influence from their friends, it is time you redefine your company.

It is unbearable to see your friends use and stick up to your lane of quitting.

It does not always work that way especially for someone who is addicted.

You have to make hard decisions, and one of them will be staying away from friends who will make you want to use.

They do not cease being your friends; it is only that you want some personal space to work on getting out of the muddle.

Get back to healthy eating Addiction, whatever kind, will take away your appetite.

With opioids, food will not be one of your favorite things.

You will want to get high and stay that way for as long as you can.

Going back to healthy eating is one great way to beat addiction at its own game.

Stock up healthy foods and be ready to cook.

Be strict with your meal time and make up for any opportunities you miss.

Your body will get all nutrients you need to stay in shape and be able to face anything that the addiction throws your way.

With a full stomach, you will have the mental power to reject any temptations to get high.

You will also have the energy to go for exercise and before you know it your bad days will be behind you.

Go for counseling Once you walk down the path of addiction, you are no longer the same.

You may have the illusion of control, but the drug is what drives you.

Talking to a professional may help you.

You have probably read stories of people who were deep into drug use, but they got out.

Counseling could be one of the ways to get you back to your feet.

You will be talking to someone who has dealt with many cases like yours.

You will get necessary guidance on how to stop using and once more be in full control of your life.

Counseling might not work for all cases, but it is worth your try.

Go for a detox For those who are deep into the addiction, you may need more than self-belief to get clean.

Going for an opioid detox can help you not only stop using but also clean up your body from past use.

You will be dealing with professionals who know how to get the dirt out and leave you as clean as new.

There is nothing complicated with detox; it is a matter of getting clean for a couple of days, and you have a clean slate.

The medical option This is the alternative you should go to if the rest of the options do not work.

It is the most recommended method for getting out of opioid addiction, but if it comes to the last resort, you may not have any other cards left.

Bupurenorphine has been known to put a stop to the opioid receptors in your brain without the risks of euphoria or sedation.

You should note that you are not making a switch from one kind of drug abuse to another; the prescription has to come from a competent physician.

Methadone is another form of medication you can go for.

It is a synthetic form of opioid except that it does not come with euphoria and sedation.

It effectively changes the effects of pain by mimicking opioids.

It helps addicts get back into shape thus be able to go for addiction therapy and deal with the underlying problem.

Methadone prescription is not one you can get just anywhere; it has to be approved and facilitated by a government program.

Wrap up Honestly, it is not going to be easy shaking off your opioid addiction.

Many people try only to find themselves using again.

You will need more than a mere desire to overcome your dependency.

One of the easiest approaches to go about it is declaring that since you do not gain a thing from it; you have no business using.

Once you have the inner push to get out of addiction, nothing is going to stop you.

Believe in yourself, and you will be surprised how willpower can move mountains.

How to Increase Testosterone and Sperm Count in Men

Male fertility is determined by the sperm count a man has.

In order for him to be fertile and be able to make a women pregnant your per ml ejaculate should contain more than 20 million sperm cells.

Moreover, the volume of seminal fluid should be adequate.

Reasons for Reduced Sperm Count

Over time, the number of sperms produced by the male body is reduced due to several reasons.

Age – A large number of men experience a drop in their sperm count as they get older.

As you get over 40, your testosterone levels begin dropping and this can affect both semen volume as well as sperm count.

Stress – Extreme stress whether it relates to home or work can take a toll on both your erectile and reproductive health.

Erectile dysfunction, relationship issues, work pressures etc., can all increase stress.

However, you can overcome these problems with the help of some simple relaxation techniques.

Substance Abuse – Drugs like cocaine and marijuana can also result in a low sperm count. Not just this, it can also lead to impotence.

  • Frequent ejaculation of semen
  • Excessive smoking and drinking
  • Obesity
  • Physical and mental over-exertion
  • Continuous use of anabolic steroids
  • Deficiency in zinc
  • Prostate gland infections

Simple ways to increase your sperm count

  • Increase your zinc intake- Zinc is the most important mineral as far as your semen health and volume is concerned.
  • It is worth noting that almost 70% of zinc in your body is contained in semen.
  • You lose it with every ejaculation and hence it is extremely important to replenish it.

Foods which are rich in zinc include red meat, oysters, bananas and poultry

  • Vitamin C: Vitamin C not only helps increase your sperm count but also helps reduce sperm motility.
  • Avoid wearing tight underpants- Though tight underpants do not lead to any sort of erectile problems, they can spell disaster for your sperm health and count.

This is because they tend to increase temperature in your testicles which affect semen production and sperm health.

  • Reduce your caffeine intake- Soft drinks and coffee is generally rich in caffeine
  • Stop Smoking- smoking lead to erectile problems by building plaque in your arteries and leads to a drop in sperm count.

On top of that,it also damages sperm and lead to infertility in men.

Exercise Regularly

Regular exercise is good for your sperm production since it not only increases blood circulation to the penis and the testes but also helps increase testosterone production.

However, cycling is something you must avoid.

Drink a lot of water

Water keeps your body well hydrated so that you can produce enough semen.

You should drink at least eight glasses of water every day.

Normal Solutions to Increase Sperm Production

  • It is advisable to control ejaculation to once in 3 days.
  • You should totally avoid smoking and drinking.
  • Even a couple of drinks a day are capable of increasing estrogen levels in the body by affecting the liver and reducing the sperm count.
  • A few cigarettes a day also lead to reduced sperm count.
  • Your food must be balanced and nutritious. The food must be low in fat content but be rich in protein.

Whole grains and vegetables are ideal food. Coffee, steroids, spicy food items, and astringent food must be shunned.

  • If you are obese, weight loss is very important, since obesity results in imbalances of testosterone and estrogen levels.
  • Regularly undertake exercise, yoga, and meditation to relax body and mind.
  • If the problem is due to medical reasons, then natural supplements are a big help to increase semen volume.
  • Keep Your Testicles Cool

First and foremost, you must avoid overheating of your testicles.

This is because too much of heat can kill your sperm and reduce semen volume.

Wear a Jockstrap while Exercising

Exercise is great for your semen production. First of all, it assist in increasing blood flow to the testicles.

Secondly, it helps boost testosterone which is the hormone that controls your semen production.

However, you must wear a jockstrap while exercising or playing a sport to prevent any injury to your testicles.

It’s worth nothing that even a single blow to your testicles can hurt you and kill your sperm.

Reduce Stress

Stress hormones block leydig cells in your testicles and this affects your testosterone production adversely.

A drop in testosterone leads to a drop in your sperm count and semen volume.

Thus, try to manage stress with techniques like yoga, tai chi, meditation, laughter therapy etc.

If you work for 10-12 hours a day, you are likely to have a low sperm count.

Try to get enough rest and sleep after a tiring day so that your body can produce testosterone and sperm more effectively.

Top-notch pills are clinically proven and recommended by doctors too.

They do not have any negative side effects.

Herbal or Natural Semen Enhancers

Such semen enhancers can be a big help.

Not only do they help boost your semen volume but also help increase your low sperm count.

These supplements are a blend of all natural ingredients

A good diet that is rich in minerals and a healthy and active lifestyle can help you increase your sperm-count and fertility.

Besides this, there are some natural semen supplements that can boost both your semen volume and sperm count naturally.

Such supplements are a power blend of herbal extracts, vitamins and minerals that can make you produce and ejaculate up to 5 times more semen with greater force and power.

They can be great for both your sexual and reproductive health.

They not only increase semen volume and sperm count but also increase blood flow to the penis to ensure harder and stiffer erections.

Another advantage of such supplements is that they can make you last much longer in bed.

A good quality supplements are clinically approved and do not have any sort of negative side effects at all.

Such supplements can increase your semen production manifolds within a few months and give a big thrust to your fertility.

Not only this, they also ensure rock hard erections, better staying power and insatiable desire to have sex.

This will add spice to your sex life and I am sure your woman is going to love it.

How to Convince Your Doctor You Need Medication

When you are sick, taking an active role in your medication will get you the best services.

You can start by improving your personal relationship with your doctor to convince him/her that you need medication.

You should let your doctor know about your current and past medication.

Especially, if you are allergic to some medications, your doctor should know about it.

If you have any medicines you are currently taking, you should bring them with you.

Don’t forget to bring vitamins, x-rays, medical records, test results with you to the appointment so that doctor can see your seriousness.

How to Convince Your Doctor You Need Medication

Let your doctor be the doctor.

Only a doctor can diagnose and prescribe, for very good reason.

They’ve had the training to tell what’s wrong and how to treat it.

If you suspect a problem, mention it, but don’t argue about it.

Make use of this knowledge.

Bring information.

There are plenty books and web sites that have the chemical constituents of various herbs.

This information is vital to a discussion, because some of these constituents are similar to medications.

Beware of interactions.

If you get a list of the interactions that would be useful for your doctor, you should be aware of side effects and precautions.

An example of the need for precautions includes pregnancy and auto-immune disorders.

These can be a problem when mixed with herbal remedies.

Be honest about what you take.

Tell your doctor the name of all supplements and listen to what he says.

Even “minor” things like garlic and fish oil can cause problems.

As an example, both garlic and fish oil are blood thinners.

Not all conditions can be treated successfully using alternative remedies, and depending on them alone could be deadly.

When dealing with serious illness, it is important that you and your doctor or doctors form a team.

If you feel a supplement will be beneficial, talk it over with your doctor, but rely on his or her expertise in the matter.

Talk to your pharmacist.

Pharmacists usually know more about supplements than doctors, and can be a great ally.

They can provide information to take to your doctor and can spot a potentially deadly interaction quickly…if they know you’re taking it.

To ensure good communication, it is important to:

Choose a doctor who is an attentive listener.

Although it is important to have a doctor who is knowledgeable in his or her specialty, it is also essential to choose a doctor who will listen carefully to your health concerns.

Choose the doctor who specializes in your particular condition.

You may need a general health care practitioner, or you may be better off with a doctor that specializes in your particular area of illness or injury.

Choose a doctor with whom you feel comfortable speaking about difficult topics and sensitive issues.

Some patients prefer to visit a doctor of the same gender or who speaks the same first language in order to feel more comfortable talking about health problems.

Additionally, some patients only feel comfortable divulging details of their personal lifestyles to particular doctors.

If you don’t understand something, you should ask.

Some people are afraid to speak up.

You doctor will assume that you understand everything, if you do not ask questions.

You should write down the questions in a piece of paper, if you have questions before the appointment.

If you need more time to talk to your doctor, you need to let them know.

If your doctor is busy, a nurse or a physician assistant may be able to help you.

If everyone is busy, you should schedule another appointment to answer your questions.

Describe your symptoms clearly and briefly.

Tell the doctor the time symptoms started, how they make you feel, what you may be doing when the symptoms start what makes them better etc.

Tell your doctor what over-the-counter medicines you are taking such as vitamins, herbal products or any other supplements.

Don’t be embarrassed about sensitive issues.

Chances are the doctor has heard it all before.

You also need to be honest with your doctor about your diet, physical activity, if you smoke, your drug or alcohol use and your sexual activity.

And please mention if you are being treated by other doctors. – withholding information can be harmful.

When you are given medicines and other treatments make sure you understand how to take the medicine

If you cannot remember all instructions from your doctor, you should write down your instructions.

Some people use a tape recorder.

Your doctor may even have brochures or other education materials for you.

Ask your doctor for his/her contact’s information.

The quality of care you receive may depend directly on how well you and your physician exchange information with each other.

For your own personal health, it is important to be sure to do your part to be open, honest, and clear with your doctor about your health concerns.

Additionally, it is important to search until you find a practitioner who is knowledgeable in your area of concern and can clearly communicate to you your diagnosis and treatment options.

Understand what to do if you miss a dose and if there are any foods or activities that you should avoid while on the medication.

Find out how long the medication or treatment will last.

Ask about the side effects; if it’s covered by your insurance, are there genetic substitutes.

Your pharmacist can also help answer questions regarding medications.

If you need to, bring a family member or friend to your appointment; that person can take notes as well as provide moral support and can help you remember what was discussed.

Understand everything before you leave the doctor’s office.

If you do not understand something, ask to have it explained again.

Good relationships are based around the ability to communicate problems, wishes, and fears clearly and effectively, even in the relationship between you and your doctor.

If you and your doctor cannot clearly communicate with each other, you may suffer from a decreased quality of care, simply because your doctor did not understand your needs, diagnosed you improperly because of a lack of information, or gave you inadequate aftercare instructions.

Not all doctors will respond positively to these tips, so if using alternatives is important to you, find a good doctor who is open minded.

It is very important that you don’t self-diagnose and self-prescribe; the doctor is on your side and wants you to be healthy.

Guide to the Different Types of Pharmaceuticals

With the presence of varying medical conditions, it is common knowledge that there are different types of pharmaceutical drugs on the market today.

While you may understand this basic knowledge, you may not be able to tell which drug treats which ailment, its mechanism of action and its interaction.

Without such understanding, it is impossible to understand which over-the-counter drug to use under a certain health condition.

Disappointing as this may sound, there is no need to worry over it as this article has got your back.

There is a range of pharmaceutical drugs in pharmaceuticals store today.

Here is a guide to some different types of pharmaceuticals.

1. Antibiotics

Otherwise known as antibacterial, antibiotics are a type of pharmaceutical drug used to treat bacterial infections.

They work by either inhibiting the growth of the bacteria or killing the bacteria.

While antibiotics cannot treat a viral infection such as flu, coughs and cold, they can prevent them from progressing into severe infections.

Penicillin, cephalosporins, macrolides, fluoroquinolones, sulfonamides, tetracyclines and aminoglycosides are the seven types of approved antibiotics.

Each antibiotic has a specific bacterial infection that it treats, hence should be prescribed by a doctor for desired results unless you deliberately want to experience the wrath of the medications (which you don’t).

2. Analgesic

Popularly sold under the name painkillers, analgesics are pharmaceuticals used to alleviate pain or symptoms of pain.

When the cells in your body get injured, they release a chemical referred to as prostaglandins making the nerve ending to detect it and transmit the pain to the nervous system and the brain.

By taking the painkillers, damaged cells are inhibited from producing prostaglandins chemicals hence the decrease if not a complete termination of pain.

The most common and highly effective painkillers in the store today are ibuprofen and acetaminophen.

Other types of analgesic rugs include opioid drugs like oxycodone and morphine, paracetamol and nonsteroidal anti-inflammatory drugs (NSAIDs).

The type of painkiller administered by your doctor varies in relation to the level of pain you are experiencing.

3. Antimalarial Drugs

From the acronym itself, you can tell that this drug is used in the treatment of malaria.Various examples of antimalarial drugs include quinine, proguanil amodiaquine, mefloquine, sulfonamides, and chloroquine.

They are classified into two distinct yet related classes: the suppressive and casual malarial drugs.

Whereas the latter kills malaria before the parasite reaches the bloodstream, the former kills malaria that is already existent in your bloodstream.

The main mechanism of action of these pharmaceuticals is, therefore, killing the virus in an attempt of curing or preventing malaria from developing.

While other drugs are taken once the symptoms appear or when you feel sick, the antimalarial drugs can be taken two days before travelling to a malaria zone.

These decreases your chances of contracting the ailment while in this area.

However, if you are sick and have begun taking the anti-malarial dosage, you should ensure their completion even if when you feel healthy after days of taking the drugs.

4. Antiseptics

These pharmaceuticals are almost similar to antibiotics but should not be confused with antibacterial.

While antibiotics treat bacterial infections on the lymphatic system, antiseptics are microbial used to treat bacterial infection on your skin.

Ideally, antiseptic is used in the treatment of the skin before cuts are made during surgical operations.

They work through reducing or killing these bacterial infections.

Alcohol, boric acid, hydrogen peroxide and iodine are examples of antiseptics.

The strength of antiseptics differs in relation to their effect on the tissue.

A powerful antiseptic like mercuric chloride irritates delicate tissues in spite of its strength.

Therefore, consider getting its prescription from your doctor as they can never go wrong with the perfect antiseptic for your condition.

5. Mood Stabilizers

While mood swings are normal, some may be too frequent hence abnormal.

Mood stabilizers are pharmaceutical drugs used to treat and prevent abnormal mood behaviors like bipolar disorder, anxiety and even depression.

They comprise drugs like lithium, asenapine, carbamazepine, lamotrigine and valproate.

Although their mechanism of operation is not well understood, they are thought of being pharmaceuticals that affect certain neurotransmitters in the brain responsible for mood.

They should be taken moderately since overdoing may have a serious effect on your health.

6. Stimulants

Also referred to as psych stimulants or colloquially as uppers stimulants, these are drugs that increase the activity of the brain and the entire body at large.

Classified under the class stimulants are drugs such as nicotine, prescription stimulants like Adderall and Ritalin, methamphetamine and cocaine.

Although effective only for a short period and can sometimes be highly addictive to the user.

It is not easy to explain their mechanism of action because each stimulant has unique properties making them have distinct mechanisms of action but similar outcomes.

Unless authorized by your medical practitioner, refrain from giving your child any stimulant more so the unprescribed stimulants as this may affect their mental state if not their life.

There is, however, no need to worry about their legality because the drugs are legal in most states.

Bottom line While all these pharmaceuticals are distinct in their mechanism of action and the illness, certain similarities are seen in all of them.

Firstly all of these drugs cannot be combined with a particular set of drugs.

Correspondingly they cannot be used under certain medical conditions.

It is, therefore, necessary to always inform your doctor of your current medications and your current and past medical status.

Doing so will help them know if the drugs are suitable for you.

Failure to observe this puts your health at risk because the drugs react by worsening your current situation or lowering the functionality of the medication you are using.

Also, understanding these different types of pharmaceuticals is not an assurance that all will work well for you.

You need to purchase the drugs from a reputable store as it serves as a guarantee of quality drugs and takes the medications as directed by your physician.

Now you know, don’t you?